Population ageing in sub-Saharan Africa (SSA) is occurring rapidly amid persistent socioeconomic inequities, yet little is known about how disadvantages accumulate across the life course to shape older adults’ wellbeing. Drawing on a scoping review methodology guided by Arksey and O’Malley (2005) and enhancements by Levac et al. (2010), this review synthesizes evidence from empirical, theoretical, and policy literature published between 1990 and mid-2025 to map how cumulative social and economic disadvantage unfolds across life stages and affects later life outcomes in SSA. Sixty-odd studies from 18 countries were included, spanning quantitative, qualitative, and mixed-methods designs. The review reveals that early life adversity such as low childhood socioeconomic status, limited education, and health shocks sets trajectories that constrain opportunities for formal employment, asset accumulation, and social mobility. These constraints are compounded over adulthood, especially among women and rural populations who disproportionately engage in informal work, caregiving, and face structural exclusions such as lack of pension coverage. The accumulation of disadvantage across life stages is consistently associated with poorer physical and mental health, reduced financial security, social isolation, and heightened vulnerability in old age. While a minority of studies explicitly frame their analyses in life course or cumulative disadvantage theory, many implicitly invoke life trajectory thinking. Longitudinal data remain scarce, and intersectional, contextually grounded, and comparative research is limited. The review underscores the need to adapt cumulative disadvantage models to the African context, accounting for macro-historical shocks, informal economies, kin networks, and nonmaterial assets, and to invest in life course–oriented policies. Interventions aimed at early childhood, education, inclusive social protection, gender equity, and integrated ageing frameworks are vital to interrupt compounding disadvantage and promote equitable ageing in SSA.